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Activated neu induces rapid tumor progression

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dc.contributor.author Guy, C. T. en_US
dc.contributor.author Cardiff, R. D. en_US
dc.contributor.author Muller, W. J. en_US
dc.date.accessioned 2006-06-22T14:16:45Z
dc.date.available 2006-06-22T14:16:45Z
dc.date.issued 1996-03 en_US
dc.identifier.citation J Biol Chem 271, 7673-8 (1996) en_US
dc.identifier.uri http://hdl.handle.net/1807.1/176
dc.description This article is hosted on a website external to the CBCRA Open Access Archive. Selecting “View/Open” below will launch the full-text article in another browser window.
dc.description.abstract Expression of the activated neu oncogene in transgenic mice has been associated with both the synchronous (single-step) and the stochastic (multistep) transformation of the mammary epithelium. To determine the basis for these conflicting observations, additional strains of transgenic mice carrying the activated neu oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer were produced. Activated neu transgene expression, as measured by in situ hybridization and ribonuclease protection assays, resulted in rapid conversion of the normal mammary epithelium to malignant phenotype in three independent strains of mice. Expression of the transgene in male mice led to epithelial hyperplasia of the epididymis and male infertility but not malignancy. These results indicate that tissue context is an important parameter in malignant progression and that expression of appropriate levels of activated neu is sufficient for rapid production of mammary tumors in transgenic mice. en_US
dc.description.provenance Made available in DSpace on 2006-06-22T14:16:45Z (GMT). No. of bitstreams: 1 Guy.1996.7673.html: 413 bytes, checksum: a8f7449969cb5a6caa69ec2071c8c6d0 (MD5) Previous issue date: 1996-03 en
dc.format.extent 413 bytes
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dc.language.iso en en_US
dc.publisher American Society for Biochemistry and Molecular Biology en_US
dc.relation.uri http://www.asbmb.org/ en_US
dc.title Activated neu induces rapid tumor progression en_US
dc.type Article en_US

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