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Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells

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dc.contributor.author Huynh, H. en_US
dc.contributor.author Yang, X. en_US
dc.contributor.author Pollak, M. en_US
dc.date.accessioned 2006-06-19T17:40:58Z
dc.date.available 2006-06-19T17:40:58Z
dc.date.issued 1996-01 en_US
dc.identifier.citation J Biol Chem 271, 1016-21 (1996) en_US
dc.identifier.uri http://hdl.handle.net/1807.1/58
dc.description This article is hosted on a website external to the CBCRA Open Access Archive. Selecting “View/Open” below will launch the full-text article in another browser window.
dc.description.abstract MCF-7 human breast cancer cells are commonly used to model tissues responsive to estrogens and antiestrogens. We examined the effects of estradiol and the antiestrogen ICI 182780 on MCF-7 cell proliferation and insulin-like growth factor binding protein 3 (IGFBP-3) gene expression. ICI 182780-induced growth inhibition was associated with increased transcription of the IG-FBP-3 gene, increased IGFBP-3 mRNA abundance, and increased IGFBP-3 protein accumulation in the conditioned medium. The growth stimulatory effect of estradiol was associated with opposite effects, and the correlation between cellular proliferation and IGFBP-3 mRNA abundance was strong (r = -0.91). Recombinant IGFBP-3 inhibited basal and estradiol-stimulated MCF-7 cell proliferation, and an IGFBP-3 antisense oligodeoxynucleotide abolished antiestrogen-induced growth inhibition. These results provide evidence for an estradiol and antiestrogen-regulated IGFBP-3 growth inhibitory autocrine pathway in MCF-7 cells. en_US
dc.description.provenance Made available in DSpace on 2006-06-19T17:40:58Z (GMT). No. of bitstreams: 1 Huynh.1996.1016.html: 411 bytes, checksum: bc77f7d404f328e1a3eb45b5b2b20f31 (MD5) Previous issue date: 1996-01 en
dc.format.extent 411 bytes
dc.format.mimetype text/html
dc.language.iso en en_US
dc.publisher American Society for Biochemistry and Molecular Biology en_US
dc.relation.uri http://www.asbmb.org/ en_US
dc.title Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells en_US
dc.type Article en_US

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