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Mammographic Density and the Risk and Detection of Breast Cancer

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dc.contributor.author Boyd, N. F.
dc.contributor.author Guo, H.
dc.contributor.author Martin, L. J.
dc.contributor.author Sun, L.
dc.contributor.author Stone, J.
dc.contributor.author Fishell, E.
dc.contributor.author Jong, R. A.
dc.contributor.author Hislop, G.
dc.contributor.author Chiarelli, A.
dc.contributor.author Minkin, S.
dc.contributor.author Yaffe, M. J.
dc.date.accessioned 2010-01-08T16:33:08Z
dc.date.available 2010-01-08T16:33:08Z
dc.date.issued 2007-01-18
dc.identifier.citation Boyd, N.F., Guo, H., Martin, L.J., Sun, L., Stone, J., Fishell, E., Jong, R.A., Hislop, G., Chiarelli, A., Minkin, S. & Yaffe, M.J. Mammographic density and the risk and detection of breast cancer. N Engl J Med 356, 227-36 (2007). en_US
dc.identifier.uri http://hdl.handle.net/1807.1/816
dc.description http://content.nejm.org/ en_US
dc.description This article is hosted on a website external to the CBCRA Open Access Archive. Selecting "view/open" will launch the full-text article in another browser window. en_US
dc.description.abstract Background: Extensive mammographic density is associated with an increased risk of breast cancer and makes the detection of cancer by mammography difficult, but the influence of density on risk according to method of cancer detection is unknown. Methods: We carried out three nested case–control studies in screened populations with 1112 matched case–control pairs. We examined the association of the measured percentage of density in the baseline mammogram with risk of breast cancer, according to method of cancer detection, time since the initiation of screening, and age. Results: As compared with women with density in less than 10% of the mammogram, women with density in 75% or more had an increased risk of breast cancer (odds ratio, 4.7; 95% confidence interval [CI], 3.0 to 7.4), whether detected by screening (odds ratio, 3.5; 95% CI, 2.0 to 6.2) or less than 12 months after a negative screening examination (odds ratio, 17.8; 95% CI, 4.8 to 65.9). Increased risk of breast cancer, whether detected by screening or other means, persisted for at least 8 years after study entry and was greater in younger than in older women. For women younger than the median age of 56 years, 26% of all breast cancers and 50% of cancers detected less than 12 months after a negative screening test were attributable to density in 50% or more of the mammogram. Conclusions: Extensive mammographic density is strongly associated with the risk of breast cancer detected by screening or between screening tests. A substantial fraction of breast cancers can be attributed to this risk factor. en_US
dc.description.provenance Submitted by Kelly Lee (klee@cbcra.ca) on 2010-01-08T16:33:08Z No. of bitstreams: 1 Boyd.html: 459 bytes, checksum: 0034b83cfd53e946748e9092a8738c20 (MD5) en
dc.description.provenance Made available in DSpace on 2010-01-08T16:33:08Z (GMT). No. of bitstreams: 1 Boyd.html: 459 bytes, checksum: 0034b83cfd53e946748e9092a8738c20 (MD5) Previous issue date: 2007-01-18 en
dc.language.iso en en_US
dc.publisher Massachusetts Medical Society en_US
dc.title Mammographic Density and the Risk and Detection of Breast Cancer en_US
dc.type Article en_US

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